Endocrinology/HormonesWithoutMuchPituitaryRole/GlucagonAndInsuliln/Glucagon/ControlBasic/Fasting
| When blood glucose is decreased, negative feedback facilitates glucagon (synthesis, secretion, and blood concentration). |
(Synthesis, secretion, and blood concentration of) glucagon increases blood glucose.
Glucagon has a certain (baseline) amount of synthesis, secretion, blood concentration, and blood glucose-increasing effect before fasting.
① Subject had fasted. Blood glucose is decreased due to the fasting. Glucacon (synthesis, secretion, and blood concentration) increases blood glucose. These are in the opposite direction (blue).
② Since these are in the opposite direction (blue), negative feedback facilitates (red) glucagon (synthesis, secretion, and blood concentration). Because of this, the blood glucose-increasing effect of glucagon strengthens, and the decrease in blood glucose (blue downward unfilled arrow) disappears (decreased blood glucose increases to the baseline).
Like, when room temperature is decreased (winter), heater (function) is facilitated, this also is blue→red negative feedback.
Challenge Quiz
Blood glucose is increased decreased due to the fasting, glucagon (synthesis, secretion, and blood concentration increases decreases blood glucose. Since these are in the same direction opposite direction , negative feedback inhibits facilitates glucagon. Because of this, the initial transition dissapears and the blood glucose increases decreases (towards the baseline).
When blood glucose is decreased, negative feedback inhibits facilitates glucagon (synthesis, secretion, and blood concentration).