Endocrinology/HormonesWithoutMuchPituitaryRole/GlucagonAndInsuliln/Glucagon/ControlBasic/Meal
| When blood glucose is increased, negative feedback inhibits glucagon (synthesis, secretion, and blood concentration). |
(Synthesis, secretion, and blood concentration) of glucagon increases blood glucose.
Glucagon has a certain (baseline) amount of synthesis, secretion, blood concentration, and blood glucose-increasing effect before meal.
① Subject had meal. Blood glucose is increased due to the meal. Glucacon (synthesis, secretion, and blood concentration) increases blood glucose. These are in the same direction (red).
② Since these are in the same direction, negative feedback inhibits (blue) glucagon (synthesis, secretion, and blood concentration). Because of this, the blood glucose-increasing effect of glucagon weakens, and the increase in blood glucose (red upward unfilled arrow) disappears (increased blood glucose decreases to the baseline).
Like, when room temperature is increased (summer), heater (function) is decreased, this also is red→blue negative feedback.
Challenge Quiz
食事により血糖は 上昇 低下 し、グルカゴン（の生成、内分泌、血中濃度）は血糖を 上昇 低下 させる。これらは 同じ方向 逆の方向 なので、負のフィードバックはグルカゴンを 低下 亢進 させる。この調節により、血糖の最初の変化は消える、すなわち血糖は(ベースラインへ向けて) 上昇 低下 する。
血糖が上昇した時、負のフィードバックはグルカゴン（の生成、内分泌、血中濃度）を 亢進 低下 させる。