SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/EffectOfDecrease
| With the decrease of the synthesis, secretion, and blood concentration of ADH, the number of water channels decreases . |
video prior to the decrease in ADH
Prior to ADH decreasing (at baseline), we will make the assumption that the subject is in homeostasis with normal plasma and urine osmolarities (isotonic) and volumes.
video just after the decrease in ADH
Step 1: Suppose that the synthesis, secretion, and blood concentration of ADH decreases.
The water channel-increasing effect of ADH decreases, thereby decreasing the number of water channels. This decreases the reabsorption of water by the kidney.
video showing the changes in plasma and urine after the decrease in ADH
The ratio of Na+ to water entering the plasma due to reabsorption increases. This increases plasma osmolarity (hypertonic). Because a higher ratio of Na+ to water leaves the tubule due to reabsorption, the fluid remaining in the tubule has a lower osmolarity (hypotonic). Also, with a decrease in water reabsorption, there is more water remaining in the tubule. Overall, the urine becomes less concentrated (hypotonic) and higher in volume.
Challenge Quiz
With the decrease of the synthesis, secretion, and blood concentration of ADH, the number of water channels in the kidney increases decreases .
With the decrease of the synthesis, secretion, and blood concentration of ADH, water reabsorption by the kidney increases decreases .
With the decrease of the synthesis, secretion, and blood concentration of ADH, urine volume increases decreases .
With the decrease of the synthesis, secretion, and blood concentration of ADH, urine osmolarity increases decreases .
With the decrease of the synthesis, secretion, and blood concentration of ADH, plasma osmolarity increases decreases .
The effect of decreasing in ADH is to contract female genital smooth muscle increase plasma osmolarity .
The effect of decreasing in ADH is to increase decrease the plasma osmolarity .