SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/EffectOfIncrease
| With the increase of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), the number of water channels increases . |
video prior to the increase in vasopressin (ADH)
Prior to vasopressin (ADH) increasing (at baseline), we will make the assumption that the subject is in homeostasis with normal plasma and urine osmolarities (isotonic) and volumes.
video just after the increase in vasopressin (ADH)
Step 1: Suppose that the synthesis, secretion, and blood concentration of vasopressin (ADH) increases.
Step 2:The water channel-increasing effect of vasopressin (ADH) increases, thereby increasing the number of water channels. This increases the reabsorption of water by the kidney.
video showing the changes in plasma and urine after the increase in vasopressin (ADH)
Step 3:The ratio of Na+ to water entering the plasma due to reabsorption decreases. This decreases plasma osmolarity (hypotonic). Because a lower ratio of Na+ to water leaves the tubule due to reabsorption, the fluid remaining in the tubule has a higher osmolarity (hypertonic). Also, with an increase in water reabsorption, there is less water remaining in the tubule. Overall, the urine becomes more concentrated (hypertonic) and lower in volume.
Challenge Quiz
With the increase of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), the number of water channels in the kidney increases decreases .
With the increase of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), water reabsorption by the kidney increases decreases .
With the increase of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), urine volume increases decreases .
With the increase of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), urine osmolarity increases decreases .
With the increase of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), plasma osmolarity increases decreases .
The effect of increasing in vasopressin (anti-diuretic hormone, ADH) is to contract female genital smooth muscle decrease plasma osmolarity .
The effect of increasing in vasopressin (anti-diuretic hormone, ADH) is to increase decrease the plasma osmolarity .