「Endocrinology/HormonesWithoutMuchPituitaryRole/GlucagonAndInsuliln/Glucagon/ControlBasic/Fasting」の版間の差分

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{{Point|When blood glucose is decreased, negative feedback facilitates glucagon (synthesis, secretion, and blood concentration).}}
{{Point|When blood glucose is decreased, negative feedback facilitates glucagon (synthesis, secretion, and concentration in blood).}}
[[メディア:glucagon-fast.mp4|動画と音声での説明]]
[[メディア:glucagon-fast.mp4|動画と音声での説明]]
[[ファイル:GlucagonBaselineJpn.jpg|left|500px]]
[[ファイル:GlucagonBaselineJpn.jpg|left|500px]]
(Synthesis, secretion, and blood concentration of) glucagon increases blood glucose.
(Synthesis, secretion, and concentration in blood of) glucagon increases blood glucose. Before fast, glucagon has certain levels of synthesis, secretion, concentration in blood, and blood glucose-increasing effect.
 
Glucagon has a certain (baseline) amount of synthesis, secretion, blood concentration, and blood glucose-increasing effect before fasting.
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[[ファイル:glucagon-fast.jpg|left|500px]]
[[ファイル:glucagon-fast.jpg|left|500px]]
① 絶食しました。絶食により血糖は低下します。グルカゴン（の生成、内分泌、血中濃度）は血糖を上昇させます。これらは<font color="#00f">逆の方向（青）</font>です。
① Subject had fasted.  Blood glucose is decreased due to the fasting. Glucacon (synthesis, secretion, and blood concentration) increases blood glucose. These are in the <font color="#00f">opposite direction (blue)</font>.
 
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[[ファイル:glucagon-fast-FB.jpg|left|500px]]
[[ファイル:glucagon-fast-FB.jpg|left|500px]]
② これらは<font color="#00f">逆の方向（青）</font>なので、負のフィードバックはグルカゴン（の生成、内分泌、血中濃度）を<font color="#ff0000">亢進（赤）</font>させます。これにより、グルカゴンの血糖上昇作用が増強し、血糖の低下（青い下向きの白抜き矢印）が消えます（低下していた血糖はベースラインの血糖へ向けて上昇します）。
② Since these are in the <font color="#00f">opposite direction (blue)</font>, negative feedback <font color="#ff0000">facilitates (red)</font> glucagon (synthesis, secretion, and blood concentration). Because of this, the blood glucose-increasing effect of glucagon strengthens, and the decrease in blood glucose (blue downward unfilled arrow) disappears (decreased blood glucose increases to the baseline).
 
 
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室温が低下した時（冬）にヒーターは使う、と同様、<font color="#00f">青</font>→<font color="#ff0000">赤</font>の負のフィードバックです。
Like, when room temperature is decreased (winter), heater (function) is increased, this also is <font color="#00f">blue</font>→<font color="#ff0000">red</font> negative feedback.
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{{QuizTitle}}
{{QuizTitle}}
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//LEVEL:3  
//LEVEL:3  
//RAND  
//RAND  
絶食により血糖は{~上昇~=低下}し、グルカゴン（の生成、内分泌、血中濃度）は血糖を{~=上昇~低下}させる。これらは{~同じ方向~=逆の方向}であるので、負のフィードバックはグルカゴンを{~低下~=亢進}させる。この調節により、血糖の最初の変化は消える、すなわち血糖は(ベースラインへ向けて){~=上昇~低下}する。
Blood glucose is {~increased~=decreased} due to the fasting, glucagon (synthesis, secretion, and blood concentration {~=increases~decreases} blood glucose. Since these are in the {~same direction~=opposite direction}, negative feedback {~inhibits~=facilitates} glucagon. Because of this, the initial transition dissapears and the blood glucose {~=increases~decreases} (towards the baseline).
 


//LEVEL:2  
//LEVEL:2  
//RAND  
//RAND  
血糖が低下した時、負のフィードバックはグルカゴン（の生成、内分泌、血中濃度）を{=亢進~低下}させる。
When blood glucose is decreased, negative feedback {~inhibits~=facilitates} glucagon (synthesis, secretion, and blood concentration).
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2024年2月27日 (火) 23:53時点における最新版

POINT!
When blood glucose is decreased, negative feedback facilitates glucagon (synthesis, secretion, and concentration in blood).

動画と音声での説明

GlucagonBaselineJpn.jpg

(Synthesis, secretion, and concentration in blood of) glucagon increases blood glucose. Before fast, glucagon has certain levels of synthesis, secretion, concentration in blood, and blood glucose-increasing effect.


Glucagon-fast.jpg

① Subject had fasted. Blood glucose is decreased due to the fasting. Glucacon (synthesis, secretion, and blood concentration) increases blood glucose. These are in the opposite direction (blue).


Glucagon-fast-FB.jpg

② Since these are in the opposite direction (blue), negative feedback facilitates (red) glucagon (synthesis, secretion, and blood concentration). Because of this, the blood glucose-increasing effect of glucagon strengthens, and the decrease in blood glucose (blue downward unfilled arrow) disappears (decreased blood glucose increases to the baseline).



Like, when room temperature is decreased (winter), heater (function) is increased, this also is blue→red negative feedback.


Challenge Quiz

1.

Blood glucose is increased decreased due to the fasting, glucagon (synthesis, secretion, and blood concentration increases decreases blood glucose. Since these are in the same direction opposite direction , negative feedback inhibits facilitates glucagon. Because of this, the initial transition dissapears and the blood glucose increases decreases (towards the baseline).

2.

When blood glucose is decreased, negative feedback inhibits facilitates glucagon (synthesis, secretion, and blood concentration).

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