「Endocrinology/HormonesWithoutMuchPituitaryRole/GlucagonAndInsuliln/Glucagon/ControlBasic/Meal」の版間の差分

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{{Point|When blood glucose is increased, negative feedback inhibits glucagon (synthesis, secretion, and blood concentration}}
{{Point|When blood glucose is increased, negative feedback inhibits glucagon (synthesis, secretion, and concentration in blood).}}
[[メディア:GlucagonMeal.mp4|動画と音声での説明]]
[[メディア:GlucagonMeal.mp4|動画と音声での説明]]
[[ファイル:GlucagonBaselineJpn.jpg|left|500px]]
[[ファイル:GlucagonBaselineJpn.jpg|left|500px]]
グルカゴンは血糖を上昇させます。グルカゴンは食事の前（ベースライン）にもある一定量の生成、内分泌、血中濃度、血糖上昇作用があります。
(Synthesis, secretion, and concentration in blood of) glucagon increases blood glucose.  Before meal, glucagon has certain levels of synthesis, secretion, concentration in blood, and blood glucose-increasing effect.
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[[ファイル:グルカゴン・インスリン02.jpg|left|500px]]
[[ファイル:グルカゴン・インスリン02.jpg|left|500px]]


① 食事しました。食事により血糖は上昇します。グルカゴン（の生成、内分泌、血中濃度）は血糖を上昇させます。これらは<font color="#ff0000">同じ方向（赤）</font>です。
① Subject had meal. Blood glucose is increased due to the meal. Glucagon (synthesis, secretion, and concentration in blood) increases blood glucose. These are in the <font color="#ff0000">same direction (red)</font>.
 
 
 
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[[ファイル:glucagon-meal-FB.jpg|left|500px]]
[[ファイル:glucagon-meal-FB.jpg|left|500px]]


② これらは<font color="#ff0000">同じ方向（赤）</font>なので、負のフィードバックはグルカゴン（の生成、内分泌、血中濃度）を<font color="#00f">低下（青）</font>させます。これにより、グルカゴンの血糖上昇作用が減弱し、血糖の上昇（赤い上向きの白抜き矢印）が消えます（上昇していた血糖はベースラインの血糖へ向けて低下します）。<br style="clear:both;" />  
② Since these are in the <font color="#ff0000">same direction (red)</font>, negative feedback <font color="#00f">inhibits (blue)</font> glucagon (synthesis, secretion, and concentration in blood). Because of this, the blood glucose-increasing effect of glucagon weakens, and the increase in blood glucose (red upward unfilled arrow) disappears (increased blood glucose decreases to the baseline).
 
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室温が上昇した時（夏）にヒーターは使わない、と同様、<font color="#ff0000">赤</font>→<font color="#00f">青</font>の負のフィードバックです。
Like, when room temperature is increased (summer), heater (function) is decreased, this is also <font color="#ff0000">red</font>→<font color="#00f">blue</font> negative feedback.
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22行目: 27行目:
//LEVEL:3  
//LEVEL:3  
//RAND
//RAND
食事により血糖は{~=上昇~低下}し、グルカゴン（の生成、内分泌、血中濃度）は血糖を{~=上昇~低下}させる。これらは{~=同じ方向~逆の方向}なので、負のフィードバックはグルカゴンを{~=低下~亢進}させる。この調節により、血糖の最初の変化は消える、すなわち血糖は(ベースラインへ向けて){~上昇~=低下}する。
Blood glucose is {~=increased~decreased} due to the meal, glucagon (synthesis, secretion, and concentration in blood {~=increases~decreases} blood glucose. Since these are in the {~=same direction~opposite direction}, negative feedback {~=inhibits~facilitates} glucagon. Because of this, the initial transition dissapears and the blood glucose {~increases~=decreases} (towards the baseline).
 


//LEVEL:2  
//LEVEL:2  
//RAND  
//RAND  
血糖が上昇した時、負のフィードバックはグルカゴン（の生成、内分泌、血中濃度）を{~亢進~=低下}させる。
When blood glucose is increased, negative feedback {~facilitates~=inhibits} glucagon (synthesis, secretion, and concentration in blood).
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2024年2月27日 (火) 23:33時点における最新版

POINT!
When blood glucose is increased, negative feedback inhibits glucagon (synthesis, secretion, and concentration in blood).

動画と音声での説明

GlucagonBaselineJpn.jpg

(Synthesis, secretion, and concentration in blood of) glucagon increases blood glucose. Before meal, glucagon has certain levels of synthesis, secretion, concentration in blood, and blood glucose-increasing effect.

グルカゴン・インスリン02.jpg

① Subject had meal. Blood glucose is increased due to the meal. Glucagon (synthesis, secretion, and concentration in blood) increases blood glucose. These are in the same direction (red).



Glucagon-meal-FB.jpg

② Since these are in the same direction (red), negative feedback inhibits (blue) glucagon (synthesis, secretion, and concentration in blood). Because of this, the blood glucose-increasing effect of glucagon weakens, and the increase in blood glucose (red upward unfilled arrow) disappears (increased blood glucose decreases to the baseline).


Like, when room temperature is increased (summer), heater (function) is decreased, this is also red→blue negative feedback.

Challenge Quiz

1.

Blood glucose is increased decreased due to the meal, glucagon (synthesis, secretion, and concentration in blood increases decreases blood glucose. Since these are in the same direction opposite direction , negative feedback inhibits facilitates glucagon. Because of this, the initial transition dissapears and the blood glucose increases decreases (towards the baseline).

2.

When blood glucose is increased, negative feedback facilitates inhibits glucagon (synthesis, secretion, and concentration in blood).

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