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{{Point|With sweating the plasma osmolarity increases, and negative feedback increases the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH).}}
{{Point|At a uphill, the speed decreases, and negative feedback increases the engine revolution.}}
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[[ファイル:FlatBeforeUphill-Eng.jpg|left|500px]]<br>Before an uphill (at a flat baseline), we will make the assumption that the car is in homeostasis with adequate strength of the speed-increasing effect of engine revolution as well as normal speed.  
[[ファイル:FlatBeforeUphill-Eng.jpg|left|500px]]<br>Before an uphill (at a flat baseline), we will make the assumption that the car is in homeostasis with adequate strength of the speed-increasing effect of engine revolution as well as normal speed.  
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[[ファイル:UphillBeforeMiddleFeedbacktoEngine-Eng.jpg|left|500px]]
[[ファイル:UphillBeforeMiddleFeedbacktoEngine-Eng.jpg|left|500px]]
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Step 1: With uphill, car speed decreases. <br>
Step 1: With uphill, car speed decreases. <br>
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This is in the opposite direction to the speed-increasing effect of the engine revolution.  
This is in the opposite direction to the speed-increasing effect of the engine revolution. Thus, although the strength of the speed-increasing effect of engine revolution was adequate before uphill (at flat baseline), this strength is now <font color="#00f">too weak (blue)</font> to reverse the low speed produced by uphill. Control by negative feedback is needed.
 
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Thus, although the strength of the speed-increasing effect of engine revolution was adequate before uphill (at flat baseline), this strength is now <font color="#00f">too weak (blue)</font> to reverse the low speed produced by uphill.  


Control by negative feedback is needed.
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[[ファイル:UphillDuringMiddleFeedbacktoEngine-Eng.jpg|left|500px]]
[[ファイル:UphillDuringMiddleFeedbacktoEngine-Eng.jpg|left|500px]]
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Step 3: With the strength of the plasma osmolarity-decreasing effect of the reabsorption (through the water channels, which are increased by vasopressin, ADH) before sweating (at baseline) being <font color="#00f">too weak (blue)</font>, the negative feedback <font color="#ff0000">increases (red)</font> (the synthesis, secretion, and blood concentration of) vasopressin (ADH).  <br>
Step 2: With the strength of the speed-increasing effect of the engine revolution before uphill (at flat baseline) being <font color="#00f">too weak (blue)</font>, the negative feedback <font color="#ff0000">increases (red)</font> the engine revolution.  <br>
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The speed-increasing effect of engine revolution becomes stronger, which increases the speed.  This will lead to a reverse in the decreased speed because of uphill, increasing it towards normal (baseline) speed.
Step 4: The water channel-increasing effect of vasopressin (ADH) becomes stronger, which increases the number of water channels. This increases the reabsorption of water by the kidney.
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Step 5: With the increase in water reabsorption, diluted (hypotonic) solution enters the plasma. This decreases plasma osmolarity. This will lead to a reverse in the increased plasma osmolarity from sweating (hypertonic plasma), decreasing it towards normal (baseline) osmolarity (isotonic plasma). Because diluted (hypotonic) solution leaves the tubule due to reabsorption, the fluid remaining in the tubule has a higher osmolarity (hypertonic). Also, with the increase in water reabsorption, there is less water remaining in the tubule. Overall, the urine becomes more concentrated  (hypertonic) and lower in volume.
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2019年11月30日 (土) 00:28時点における最新版

POINT!
FlatBeforeUphill-Eng.jpg


Before an uphill (at a flat baseline), we will make the assumption that the car is in homeostasis with adequate strength of the speed-increasing effect of engine revolution as well as normal speed.


UphillBeforeMiddleFeedbacktoEngine-Eng.jpg



Step 1: With uphill, car speed decreases.

This is in the opposite direction to the speed-increasing effect of the engine revolution. Thus, although the strength of the speed-increasing effect of engine revolution was adequate before uphill (at flat baseline), this strength is now too weak (blue) to reverse the low speed produced by uphill. Control by negative feedback is needed.


UphillDuringMiddleFeedbacktoEngine-Eng.jpg


Step 2: With the strength of the speed-increasing effect of the engine revolution before uphill (at flat baseline) being too weak (blue), the negative feedback increases (red) the engine revolution.
The speed-increasing effect of engine revolution becomes stronger, which increases the speed. This will lead to a reverse in the decreased speed because of uphill, increasing it towards normal (baseline) speed.