Endocrinology/HormonesWithoutMuchPituitaryRole/GlucagonAndInsuliln/Glucagon/ControlBasic/Fasting

POINT!

When blood glucose is decreased, negative feedback facilitates glucagon (synthesis, secretion, and blood concentration).

動画と音声での説明

(Synthesis, secretion, and blood concentration of) glucagon increases blood glucose. Before fast, glucagon has certain levels of synthesis, secretion, concentration in blood, and blood glucose-increasing effect.

① Subject had fasted. Blood glucose is decreased due to the fasting. Glucacon (synthesis, secretion, and blood concentration) increases blood glucose. These are in the opposite direction (blue).

② Since these are in the opposite direction (blue), negative feedback facilitates (red) glucagon (synthesis, secretion, and blood concentration). Because of this, the blood glucose-increasing effect of glucagon strengthens, and the decrease in blood glucose (blue downward unfilled arrow) disappears (decreased blood glucose increases to the baseline).

Like, when room temperature is decreased (winter), heater (function) is increased, this also is blue→red negative feedback.

Challenge Quiz

1.

Blood glucose is increased decreased  正解! due to the fasting, glucagon (synthesis, secretion, and blood concentration increases decreases  正解! blood glucose. Since these are in the same direction opposite direction  正解!, negative feedback inhibits facilitates  正解! glucagon. Because of this, the initial transition dissapears and the blood glucose increases decreases  正解! (towards the baseline).

2.

When blood glucose is decreased, negative feedback inhibits facilitates  正解! glucagon (synthesis, secretion, and blood concentration).