Endocrinology/HormonesWithoutMuchPituitaryRole/GlucagonAndInsuliln/Glucagon/ControlBasic/Meal

POINT!

When blood glucose is increased, negative feedback inhibits glucagon (synthesis, secretion, and blood concentration).

動画と音声での説明

(Synthesis, secretion, and blood concentration of) glucagon increases blood glucose.

Glucagon has a certain (baseline) amount of synthesis, secretion, blood concentration, and blood glucose-increasing effect before meal.

① Subject had meal. Blood glucose is increased due to the meal. Glucacon (synthesis, secretion, and blood concentration) increases blood glucose. These are in the same direction (red).

② Since these are in the same direction (red), negative feedback inhibits (blue) glucagon (synthesis, secretion, and blood concentration). Because of this, the blood glucose-increasing effect of glucagon weakens, and the increase in blood glucose (red upward unfilled arrow) disappears (increased blood glucose decreases to the baseline).

Like, when room temperature is increased (summer), heater (function) is decreased, this also is red→blue negative feedback.

Challenge Quiz

1.

Blood glucose is increased decreased  正解! due to the meal,Glucacon (synthesis, secretion, and blood concentration increases decreases  正解! blood glucose.Since these are in the same direction opposite direction  正解!,, negative feedback inhibits facilitates  正解! the heater (function, such as by turning the power off). Because of this, the room temperature-increasing effect of the heater weakens, and the increase in room temperature (red upward unfilled arrow) disappears (increased room temperature decreases to the baseline).

食事により血糖は 上昇 低下  正解!し、グルカゴン（の生成、内分泌、血中濃度）は血糖を 上昇 低下  正解!させる。これらは 同じ方向 逆の方向  正解!なので、負のフィードバックはグルカゴンを 低下 亢進  正解!させる。この調節により、血糖の最初の変化は消える、すなわち血糖は(ベースラインへ向けて) 上昇 低下  正解!する。

2.

血糖が上昇した時、負のフィードバックはグルカゴン（の生成、内分泌、血中濃度）を 亢進 低下  正解!させる。