「SHolroydAtWeilCornellMedQatar/Urology/Kidney/Tubules/WaterChannels/EffectOfIncrease」の版間の差分

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{{Point| With an increase the number of water channels, water reabsorption from the tubule increases. 尿細管の水チャンネルが増加すると、尿細管からの水分再吸収は増加する。
{{Point| With an increase in the number of water channels, water reabsorption from the tubule increases. }}
}}
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[[ファイル:WaterChannelsBaseLine-Eng.jpg|left|500px]]
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[[メディア:WaterChannelsBaseLine-Eng.mp4|video prior to the increase in vasopressin (ADH)]]<br>
[[メディア:WaterChannelsBaseLine-Eng.mp4|video prior to the increase in vasopressin (ADH)]]<br>
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Prior to the number of water channels increasing (at baseline), we will make the assumption that the subject is in homeostasis with normal plasma and urine osmolarities (isotonic) and urine volume.水チャンネルの増加前（ベースライン）では恒常性が保たれていて、血漿浸透圧と尿浸透圧は正常（等張）、尿量も正常であるとしましょう。
Prior to the number of water channels increasing (at baseline), we will make the assumption that the subject is in homeostasis with normal plasma and urine osmolarities (isotonic) and urine volume.
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Step 1: Suppose that the number of water channels increases.
Step 1: Suppose that the number of water channels increases.
Step 2: With the increase in the number of water channels, water reabsorption from the tubule increases.図の①：最初に、水チャンネルが増加したとします。
Step 2: With the increase in the number of water channels, water reabsorption from the tubule increases.
図の②：水チャンネルの増加により尿細管からの水分再吸収は増加します。
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[[メディア:WaterChannelsEffectOfIncrease-3Eng.mp4|video showing the changes in plasma and urine after the increase in vasopressin (ADH)]]<br>
[[メディア:WaterChannelsEffectOfIncrease-3Eng.mp4|video showing the changes in plasma and urine after the increase in vasopressin (ADH)]]<br>
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Step 3: With the increase in water reabsorption, diluted (hypotonic) solution enters the plasma. This decreases plasma osmolarity (diluted, hypotonic). Because diluted (hypotonic) solution leaves the tubule due to reabsorption, the fluid remaining in the tubule has an increased osmolarity (concentrated, hypertonic). Also, with the increase in water reabsorption, there is less water remaining in the tubule. Overall, the urine becomes concentrated and decreases in volume.図の③：水分再吸収が増加し、薄い溶液（低張液）が血漿に入ります。これにより血漿浸透圧が低下し（薄く、低張になり）ます。
Step 3: With the increase in water reabsorption, diluted (hypotonic) solution enters the plasma. This decreases plasma osmolarity (diluted, hypotonic). Because diluted (hypotonic) solution leaves the tubule due to reabsorption, the fluid remaining in the tubule has an increased osmolarity (concentrated, hypertonic). Also, with the increase in water reabsorption, there is less water remaining in the tubule. Overall, the urine becomes concentrated and decreases in volume.
再吸収で薄い溶液（低張液）が尿細管から出るため、残る液の浸透圧が上昇し（濃く、高張になり）ます。水分再吸収も増加するため、尿細管に残る水分は減少します。つまり尿は濃く、少量になります。
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//LEVEL:2  
//LEVEL:2  
//RAND  
//RAND  
With an increase the number of water channels, water reabsorption from the tubule {~=increases~decreases}.尿細管の水チャンネルが増加すると、尿細管からの水分再吸収は{=増加~減少}する。
With an increase in the number of water channels, water reabsorption from the tubule {~=increases~decreases}.  


//LEVEL:2
//LEVEL:3
//RAND  
//RAND  
With an increase the number of water channels, urine volume {~=increases~=decreases}.尿細管の水チャンネルが増加すると、尿量は{~増加~=減少}する。
With an increase in the number of water channels, urine volume {~increases~=decreases}.  


//LEVEL:2
//LEVEL:3
//RAND  
//RAND  
With an increase the number of water channels, urine osmolarity {~=increases~decreases}.尿細管の水チャンネルが増加すると、尿の浸透圧は{=上昇~低下}する。
With an increase in the number of water channels, urine osmolarity {~=increases~decreases}.  


//LEVEL:2  
//LEVEL:2  
//RAND  
//RAND  
With an increase the number of water channels, plasma osmolarity {~increases~=decreases}.尿細管の水チャンネルが増加すると、血漿浸透圧は{~上昇~=低下}する。
With an increase in the number of water channels, plasma osmolarity {~increases~=decreases}.  
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2020年4月17日 (金) 12:07時点における最新版

POINT!
With an increase in the number of water channels, water reabsorption from the tubule increases.
WaterChannelsBaseLine-Eng.jpg

Prior to the number of water channels increasing (at baseline), we will make the assumption that the subject is in homeostasis with normal plasma and urine osmolarities (isotonic) and urine volume.

WaterChannelsEffectOfIncrease-2Eng.jpg

Step 1: Suppose that the number of water channels increases. Step 2: With the increase in the number of water channels, water reabsorption from the tubule increases.

WaterChannelsEffectOfIncrease-3Eng.jpg

Step 3: With the increase in water reabsorption, diluted (hypotonic) solution enters the plasma. This decreases plasma osmolarity (diluted, hypotonic). Because diluted (hypotonic) solution leaves the tubule due to reabsorption, the fluid remaining in the tubule has an increased osmolarity (concentrated, hypertonic). Also, with the increase in water reabsorption, there is less water remaining in the tubule. Overall, the urine becomes concentrated and decreases in volume.

Challenge Quiz

1.

With an increase in the number of water channels, water reabsorption from the tubule increases decreases .

2.

With an increase in the number of water channels, urine volume increases decreases .

3.

With an increase in the number of water channels, urine osmolarity increases decreases .

4.

With an increase in the number of water channels, plasma osmolarity increases decreases .

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