「SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/EffectOfDecrease」の版間の差分
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{{Point| With the decrease of the synthesis, secretion, and blood concentration of ADH, the number of water channels decreases .}} | {{Point| With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), the number of water channels decreases .}} | ||
[[メディア:6-ADHcontrol-sweat.mp4|narrated video explanation]] | [[メディア:6-ADHcontrol-sweat.mp4|narrated video explanation]] | ||
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[[ファイル:ADHbaseline.jpg|left|500px]] | [[ファイル:ADHbaseline.jpg|left|500px]] | ||
[[メディア:ADHEffectOfDcreasing-1Eng.mp4|video prior to the decrease in ADH]]<br> | [[メディア:ADHEffectOfDcreasing-1Eng.mp4|video prior to the decrease in vasopressin (ADH)]]<br> | ||
Prior to ADH decreasing (at baseline), we will make the assumption that the subject is in homeostasis with normal plasma and urine osmolarities (isotonic) and volumes. | Prior to vasopressin (anti-diuretic hormone, ADH) decreasing (at baseline), we will make the assumption that the subject is in homeostasis with normal plasma and urine osmolarities (isotonic) and volumes. | ||
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[[ファイル:ADHControlToWaterIntake1Eng.jpg|left|500px]] | [[ファイル:ADHControlToWaterIntake1Eng.jpg|left|500px]] | ||
[[メディア:ADHEffectOfDecreasing-2Eng.mp4|video just after the decrease in ADH]]<br> | [[メディア:ADHEffectOfDecreasing-2Eng.mp4|video just after the decrease in vasopressin (ADH)]]<br> | ||
Step 1: Suppose that the synthesis, secretion, and blood concentration of ADH decreases.<br> | Step 1: Suppose that the synthesis, secretion, and blood concentration of vasopressin (ADH) decreases.<br> | ||
The water channel-increasing effect of ADH decreases, thereby decreasing the number of water channels. This decreases the reabsorption of water by the kidney. | The water channel-increasing effect of vasopressin (ADH) decreases, thereby decreasing the number of water channels. This decreases the reabsorption of water by the kidney. | ||
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[[ファイル:ADHControlToWaterIntake3Eng.jpg|left|500px]] | [[ファイル:ADHControlToWaterIntake3Eng.jpg|left|500px]] | ||
[[メディア:ADHsweatControl-4Eng.mp4|video showing the changes in plasma and urine after the decrease in ADH]]<br> | [[メディア:ADHsweatControl-4Eng.mp4|video showing the changes in plasma and urine after the decrease in vasopressin (ADH)]]<br> | ||
The ratio of Na<sup>+</sup> to water entering the plasma due to reabsorption increases. This increases plasma osmolarity (hypertonic). Because a higher ratio of Na<sup>+</sup> to water leaves the tubule due to reabsorption, the fluid remaining in the tubule has a lower osmolarity (hypotonic). Also, with a decrease in water reabsorption, there is more water remaining in the tubule. Overall, the urine becomes less concentrated (hypotonic) and higher in volume. | The ratio of Na<sup>+</sup> to water entering the plasma due to reabsorption increases. This increases plasma osmolarity (hypertonic). Because a higher ratio of Na<sup>+</sup> to water leaves the tubule due to reabsorption, the fluid remaining in the tubule has a lower osmolarity (hypotonic). Also, with a decrease in water reabsorption, there is more water remaining in the tubule. Overall, the urine becomes less concentrated (hypotonic) and higher in volume. | ||
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//LEVEL:3 | //LEVEL:3 | ||
//RAND | //RAND | ||
With the decrease of the synthesis, secretion, and blood concentration of ADH, the number of water channels in the kidney {~=increases~decreases} . | With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), the number of water channels in the kidney {~=increases~decreases} . | ||
//LEVEL:2 | //LEVEL:2 | ||
//RAND | //RAND | ||
With the decrease of the synthesis, secretion, and blood concentration of ADH, water reabsorption by the kidney {increases~=decreases}. | With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), water reabsorption by the kidney {increases~=decreases}. | ||
//LEVEL:3 | //LEVEL:3 | ||
//RAND | //RAND | ||
With the decrease of the synthesis, secretion, and blood concentration of ADH, urine volume {~=increases~decreases}. | With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), urine volume {~=increases~decreases}. | ||
//LEVEL:3 | //LEVEL:3 | ||
//RAND | //RAND | ||
With the decrease of the synthesis, secretion, and blood concentration of ADH, urine osmolarity {increases~=decreases}. | With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), urine osmolarity {increases~=decreases}. | ||
//LEVEL:3 | //LEVEL:3 | ||
//RAND | //RAND | ||
With the decrease of the synthesis, secretion, and blood concentration of ADH, plasma osmolarity {~=increases~decreases}. | With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), plasma osmolarity {~=increases~decreases}. | ||
//LEVEL:3 | //LEVEL:3 | ||
//RAND | //RAND | ||
The effect of decreasing in ADH is to {contract female genital smooth muscle ~=increase plasma osmolarity }. | The effect of decreasing in vasopressin (anti-diuretic hormone, ADH) is to {contract female genital smooth muscle ~=increase plasma osmolarity }. | ||
//LEVEL:3 | //LEVEL:3 | ||
//RAND | //RAND | ||
The effect of decreasing in ADH is to {~=increase~decrease} the plasma osmolarity . | The effect of decreasing in vasopressin (anti-diuretic hormone, ADH) is to {~=increase~decrease} the plasma osmolarity . | ||
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2019年8月25日 (日) 08:41時点における版
| With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), the number of water channels decreases . |
video prior to the decrease in vasopressin (ADH)
Prior to vasopressin (anti-diuretic hormone, ADH) decreasing (at baseline), we will make the assumption that the subject is in homeostasis with normal plasma and urine osmolarities (isotonic) and volumes.
video just after the decrease in vasopressin (ADH)
Step 1: Suppose that the synthesis, secretion, and blood concentration of vasopressin (ADH) decreases.
The water channel-increasing effect of vasopressin (ADH) decreases, thereby decreasing the number of water channels. This decreases the reabsorption of water by the kidney.
video showing the changes in plasma and urine after the decrease in vasopressin (ADH)
The ratio of Na+ to water entering the plasma due to reabsorption increases. This increases plasma osmolarity (hypertonic). Because a higher ratio of Na+ to water leaves the tubule due to reabsorption, the fluid remaining in the tubule has a lower osmolarity (hypotonic). Also, with a decrease in water reabsorption, there is more water remaining in the tubule. Overall, the urine becomes less concentrated (hypotonic) and higher in volume.
Challenge Quiz
With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), the number of water channels in the kidney increases decreases .
With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), water reabsorption by the kidney increases decreases .
With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), urine volume increases decreases .
With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), urine osmolarity increases decreases .
With the decrease of the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), plasma osmolarity increases decreases .
The effect of decreasing in vasopressin (anti-diuretic hormone, ADH) is to contract female genital smooth muscle increase plasma osmolarity .
The effect of decreasing in vasopressin (anti-diuretic hormone, ADH) is to increase decrease the plasma osmolarity .