「SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/EffectOfIncrease」の版間の差分
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[[メディア:ADHEffectOfIncreasing-2Eng.mp4|video just after the increase in ADH]]<br> | [[メディア:ADHEffectOfIncreasing-2Eng.mp4|video just after the increase in ADH]]<br> | ||
Step 1: Suppose that the synthesis, secretion, and blood concentration of ADH increases.<br> | Step 1: Suppose that the synthesis, secretion, and blood concentration of ADH increases.<br> | ||
The water channel-increasing effect of ADH increases, thereby increasing the number of water channels. This increases the reabsorption of water by the kidney. | Step 2:The water channel-increasing effect of ADH increases, thereby increasing the number of water channels. This increases the reabsorption of water by the kidney. | ||
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[[ファイル:ADHEffectOfIncreasing-3Eng.jpg|left|500px]] | [[ファイル:ADHEffectOfIncreasing-3Eng.jpg|left|500px]] | ||
[[メディア:ADHEffectOfIncreasing-3Eng.mp4|video showing the changes in plasma and urine after the increase in ADH]]<br> | [[メディア:ADHEffectOfIncreasing-3Eng.mp4|video showing the changes in plasma and urine after the increase in ADH]]<br> | ||
The ratio of Na<sup>+</sup> to water entering the plasma due to reabsorption decreases. This decreases plasma osmolarity (hypotonic). Because a lower ratio of Na<sup>+</sup> to water leaves the tubule due to reabsorption, the fluid remaining in the tubule has a higher osmolarity (hypertonic). Also, with an increase in water reabsorption, there is less water remaining in the tubule. Overall, the urine becomes more concentrated (hypertonic) and lower in volume. | Step 3:The ratio of Na<sup>+</sup> to water entering the plasma due to reabsorption decreases. This decreases plasma osmolarity (hypotonic). Because a lower ratio of Na<sup>+</sup> to water leaves the tubule due to reabsorption, the fluid remaining in the tubule has a higher osmolarity (hypertonic). Also, with an increase in water reabsorption, there is less water remaining in the tubule. Overall, the urine becomes more concentrated (hypertonic) and lower in volume. | ||
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2019年8月23日 (金) 23:28時点における版
| With the increase of the synthesis, secretion, and blood concentration of ADH, the number of water channels increases . |
video prior to the increase in ADH
Prior to ADH increasing (at baseline), we will make the assumption that the subject is in homeostasis with normal plasma and urine osmolarities (isotonic) and volumes.
video just after the increase in ADH
Step 1: Suppose that the synthesis, secretion, and blood concentration of ADH increases.
Step 2:The water channel-increasing effect of ADH increases, thereby increasing the number of water channels. This increases the reabsorption of water by the kidney.
video showing the changes in plasma and urine after the increase in ADH
Step 3:The ratio of Na+ to water entering the plasma due to reabsorption decreases. This decreases plasma osmolarity (hypotonic). Because a lower ratio of Na+ to water leaves the tubule due to reabsorption, the fluid remaining in the tubule has a higher osmolarity (hypertonic). Also, with an increase in water reabsorption, there is less water remaining in the tubule. Overall, the urine becomes more concentrated (hypertonic) and lower in volume.
Challenge Quiz
With the increase of the synthesis, secretion, and blood concentration of ADH, the number of water channels in the kidney increases decreases .
With the increase of the synthesis, secretion, and blood concentration of ADH, water reabsorption by the kidney increases decreases .
With the increase of the synthesis, secretion, and blood concentration of ADH, urine volume increases decreases .
With the increase of the synthesis, secretion, and blood concentration of ADH, urine osmolarity increases decreases .
With the increase of the synthesis, secretion, and blood concentration of ADH, plasma osmolarity increases decreases .
The effect of increasing in ADH is to contract female genital smooth muscle decrease plasma osmolarity .
The effect of increasing in ADH is to increase decrease the plasma osmolarity .