「SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/ControlToWaterIntake」の版間の差分
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{{Point|When plasma osmolarity is decreased by intake of water, the negative feedback decreases (synthesis, secretion | {{Point|When plasma osmolarity is decreased by intake of water, the negative feedback decreases (synthesis, secretion, blood concentration of) ADH.}} | ||
[[メディア:6-ADHcontrol-water.mp4|narrated video explanation]]<br> | [[メディア:6-ADHcontrol-water.mp4|narrated video explanation]]<br> | ||
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[[ファイル:ADHbaseline.jpg|left|500px]] | [[ファイル:ADHbaseline.jpg|left|500px]] | ||
[[メディア:ADHcontrol-water-start.mp4|video prior to water | [[メディア:ADHcontrol-water-start.mp4|video prior to intake of water]]<br> | ||
Prior to water | Prior to intake of water, we assume our subject is in homeostasis with normal plasma and urine osmolarities and volumes. | ||
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[[ファイル:ADHControlToWaterIntake1Eng.jpg|left|500px]] | [[ファイル:ADHControlToWaterIntake1Eng.jpg|left|500px]] | ||
[[メディア:ADHcontrol-water-middle.mp4|video just after | [[メディア:ADHcontrol-water-middle.mp4|video just after intake of water]]<br> | ||
Steps 1 and 2: Water was taken. Water will enter the plasma and its osmolarity will decrease. Both intake of water and the ADH | Steps 1 and 2: Water was taken. Water will enter the plasma and its osmolarity will decrease. Both intake of water and the ADH, water channels, and reabsorption of water by the kidney will decrease plasma osmolarity, having the same effect. Thus, in this case with low plasma osmolarity, the effect of ADH, water channels, and reabsorption would be too much. | ||
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[[ファイル:ADHControlToWaterIntake2Eng.jpg|left|500px]] | [[ファイル:ADHControlToWaterIntake2Eng.jpg|left|500px]] | ||
[[メディア:WaterDuringADHcontrol.mp4|video just after ADH decreased responding to | [[メディア:WaterDuringADHcontrol.mp4|video just after ADH decreased responding to intake of water]]<br> | ||
Steps 3 and 4: With too much effect of ADH | Steps 3 and 4: With too much effect of ADH, water channels, and reabsorption, the negative feedback decreases (synthesis, secretion, blood concentration of) ADH. The ADH-facilitating effect on the water channels will decrease, decreasing the number of water channels. This decreases the reabsorption of water by the kidney. | ||
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[[ファイル:ADHControlToWaterIntake3Eng.jpg|left|500px]] | [[ファイル:ADHControlToWaterIntake3Eng.jpg|left|500px]] | ||
[[メディア:ADHcontrol-water-end.mp4|video showing the changes in plasma and urine after ADH decreased responding to | [[メディア:ADHcontrol-water-end.mp4|video showing the changes in plasma and urine after ADH decreased responding to intake of water]]<br> | ||
Step 5: The ratio of Na<sup>+</sup> to water reabsorption by the kidney increases. This means plasma osmolarity increases. The decreased plasma osmolarity from intake of water will increase returning to normal. | Step 5: The ratio of Na<sup>+</sup> to water reabsorption by the kidney increases. This means plasma osmolarity increases. The decreased plasma osmolarity from intake of water will increase returning to normal. | ||
Because a higher ratio of Na<sup>+</sup> is reabsorbed the fluid left in the tubule now has a lower osmolarity. The decrease in the number of water channels decreases water reabsorption so there is more water. Overall the urine becomes less concentrated and high volume. | Because a higher ratio of Na<sup>+</sup> is reabsorbed the fluid left in the tubule now has a lower osmolarity. The decrease in the number of water channels decreases water reabsorption so there is more water. Overall the urine becomes less concentrated and high volume. | ||
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//LEVEL:3 | //LEVEL:3 | ||
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After intake of water, the plasma osmolarity {~=decreases~increases}. This has the effect of {increasing~=decreasing} (synthesis, secretion, blood concentration of) ADH. This in turn {increases~=decreases} the production of water channels in the kidney causing {increased~=decreased} water reabsorption. Urine osmolarity will {increase~=decrease} while volume will {~=increase~decrease}. This will {decrease~=increase} plasma osmolarity, {~=returning to normal~separating from normal}. | |||
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2019年6月4日 (火) 15:39時点における版
| When plasma osmolarity is decreased by intake of water, the negative feedback decreases (synthesis, secretion, blood concentration of) ADH. |
video prior to intake of water
Prior to intake of water, we assume our subject is in homeostasis with normal plasma and urine osmolarities and volumes.
video just after intake of water
Steps 1 and 2: Water was taken. Water will enter the plasma and its osmolarity will decrease. Both intake of water and the ADH, water channels, and reabsorption of water by the kidney will decrease plasma osmolarity, having the same effect. Thus, in this case with low plasma osmolarity, the effect of ADH, water channels, and reabsorption would be too much.
video just after ADH decreased responding to intake of water
Steps 3 and 4: With too much effect of ADH, water channels, and reabsorption, the negative feedback decreases (synthesis, secretion, blood concentration of) ADH. The ADH-facilitating effect on the water channels will decrease, decreasing the number of water channels. This decreases the reabsorption of water by the kidney.
video showing the changes in plasma and urine after ADH decreased responding to intake of water
Step 5: The ratio of Na+ to water reabsorption by the kidney increases. This means plasma osmolarity increases. The decreased plasma osmolarity from intake of water will increase returning to normal.
Because a higher ratio of Na+ is reabsorbed the fluid left in the tubule now has a lower osmolarity. The decrease in the number of water channels decreases water reabsorption so there is more water. Overall the urine becomes less concentrated and high volume.
Challenge Quiz
After intake of water, negative feedback increases decreases ADH.
After intake of water, negative feedback increases decreases water channels channels in the kidney.
After intake of water, negative feedback increases decreases water reabsorption by the kidney.
After intake of water, negative feedback increases decreases urine volume.
After intake of water, negative feedback increases decreases urine osmolarity.
After intake of water, negative feedback increases decreases plasma osmolarity.
After intake of water, the plasma osmolarity decreases increases . This has the effect of increasing decreasing (synthesis, secretion, blood concentration of) ADH. This in turn increases decreases the production of water channels in the kidney causing increased decreased water reabsorption. Urine osmolarity will increase decrease while volume will increase decrease . This will decrease increase plasma osmolarity, returning to normal separating from normal .