「SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/ControlToSweating」の版間の差分
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{{Point| | {{Point|When plasma osmolarity is increased by sweating, the negative feedback increases (the synthesis, secretion and blood concentration of) ADH.}} | ||
[[メディア:6-ADHcontrol-sweat.mp4|narrated video explanation]] | [[メディア:6-ADHcontrol-sweat.mp4|narrated video explanation]] | ||
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[[ファイル:ADHControlToSweating1Eng.jpg|left|500px]] | [[ファイル:ADHControlToSweating1Eng.jpg|left|500px]] | ||
[[メディア:ADHcontrol-sweat-middle.mp4|video just after sweating]]<br> | [[メディア:ADHcontrol-sweat-middle.mp4|video just after sweating]]<br> | ||
Steps 1 and 2: The subject sweated. Water will leave the plasma and its osmolarity will increase. Sweating will increase, and the ADH/water channels/reabsorption of water by the kidney will decrease plasma osmolarity, having the opposite effect. Thus, in this case with high plasma osmolarity, the effect of ADH/water channels/reabsorption would be too little. | Steps 1 and 2: The subject sweated. Water will leave the plasma and its osmolarity will increase. Sweating will increase, and the ADH/water channels/reabsorption of water by the kidney will decrease plasma osmolarity, having the opposite effect. Thus, in this case with high plasma osmolarity, the effect of ADH/water channels/reabsorption would be too little. | ||
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[[メディア:ADHcontrol-sweat-end.mp4|video showing the changes in plasma and urine after ADH increased responding to sweating]]<br> | [[メディア:ADHcontrol-sweat-end.mp4|video showing the changes in plasma and urine after ADH increased responding to sweating]]<br> | ||
Step 5: The ratio of Na<sup>+</sup> to water reabsorption by the kidney decreases. This means plasma osmolarity decreases. The increased plasma osmolarity from sweating will decrease returning to normal. | Step 5: The ratio of Na<sup>+</sup> to water reabsorption by the kidney decreases. This means plasma osmolarity decreases. The increased plasma osmolarity from sweating will decrease returning to normal. | ||
Because a lower ratio of Na<sup>+</sup> is reabsorbed the fluid left in the tubule now has a higher osmolarity. The increase in the number of water channels increases water reabsorption so there is less water. | Because a lower ratio of Na<sup>+</sup> is reabsorbed, the fluid left in the tubule now has a higher osmolarity. The increase in the number of water channels increases water reabsorption so there is less water. Overall, the urine becomes more concentrated and low volume. | ||
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//LEVEL:2 | //LEVEL:2 | ||
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After sweating, negative feedback {~=increases~decreases} of ADH secretion. | |||
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After sweating, negative feedback {~=increase~decrease} of water channels in the kidney. | |||
//LEVEL:2 | //LEVEL:2 | ||
2019年6月4日 (火) 11:57時点における版
| When plasma osmolarity is increased by sweating, the negative feedback increases (the synthesis, secretion and blood concentration of) ADH. |
video prior to sweating
Prior to sweating, we assume our subject is in homeostasis with normal plasma and urine osmolarities and volumes.
video just after sweating
Steps 1 and 2: The subject sweated. Water will leave the plasma and its osmolarity will increase. Sweating will increase, and the ADH/water channels/reabsorption of water by the kidney will decrease plasma osmolarity, having the opposite effect. Thus, in this case with high plasma osmolarity, the effect of ADH/water channels/reabsorption would be too little.
video just after ADH increased responding to sweating
Steps 3 and 4: With too little effect of ADH/water channels/reabsorption, the negative feedback increases (the synthesis, secretion, and blood concentration of) ADH. The ADH-facilitating effect on the water channels will increase, increasing the number of water channels. This increases the reabsorption of water by the kidney.
video showing the changes in plasma and urine after ADH increased responding to sweating
Step 5: The ratio of Na+ to water reabsorption by the kidney decreases. This means plasma osmolarity decreases. The increased plasma osmolarity from sweating will decrease returning to normal.
Because a lower ratio of Na+ is reabsorbed, the fluid left in the tubule now has a higher osmolarity. The increase in the number of water channels increases water reabsorption so there is less water. Overall, the urine becomes more concentrated and low volume.
Challenge Quiz
After sweating, negative feedback increases decreases of ADH secretion.
After sweating, negative feedback increase decrease of water channels in the kidney.
The negative feedback response to an increased sweating is a(n) increase decrease in water reabsorption by the nephron.
The negative feedback response to an increased sweating is a(n) increase decrease in urine volume.
The negative feedback response to an increased sweating is a(n) increase decrease of urine osmolarity.
The negative feedback response to an increased sweating is a(n) increase decrease of plasma osmolarity.
When you sweat the plasma osmolarity decreases increases . This has the effect of increasing decreasing (the synthesis, secretion, and blood concentration of) ADH. This in turn increases decreases the number of water channels by the nephron causing increased decreased water reabsorption. Urine osmolarity will increase decrease while volume will increase decrease . This will decrease increase plasma osmolarity, returning to normal separating from normal .