「SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/ControlToWaterIntake」の版間の差分

2019年5月21日 (火) 11:54時点における版

POINT!

Intake of water will decrease plasma osmolarity. This will in turn lead to a decrease in the synthesis, secretion and blood concentration of ADH.

動画と音声での説明

飲水前の動画
Prior to drinking we assume our subject is in homeostasis with normal plasma and urine osmolarities and volumes.

Steps 1 and 2: Water was taken. Water will enter the plasma and its osmolarity will decrease. Both intake of water and the ADH/water channels/reabsorption of water by the kidney will decrease plasma osmolarity, having the same effect. Thus, in this case with low plasma osmolarity, the effect of ADH/water channels/reabsorption would be too much.

飲水直後、調節前の動画

Steps 3 and 4: With too much effect of ADH/water channels/reabsorption, the negative feedback decreases (the synthesis, secretion, and blood concentration of) ADH. The ADH-facilitating effect on the water channels will decrease, decreasing the number of water channels. This decreases the reabsorption of water by the kidney.

飲水に対してADHが低下した直後の動画

Step 5: The ratio of Na+ to water reabsorption by the kidney increases. This means plasma osmolarity increases. The decreased plasma osmolarity from intake of water will increase returning to normal. Because a higher ratio of Na+ is reabsorbed the fluid left in the tubule now has a lower osmolarity. The decrease in the number of water channels decreases water reabsorption so there is more water. So overall the urine becomes dilute and high volume.

飲水に対してADHが低下した後の血漿、尿の2次的変化の動画

Challenge Quiz

<GIFT> //LEVEL:2 //RAND The negative feedback reaction to an increased intake of water is a(n) {increase~=decrease} of ADH secretion. //LEVEL:3 //RAND

The negative feedback reaction to an increased intake of water is a(n) {increase~=decrease} of aquaporin channels in the kidney.

//LEVEL:2 //RAND The negative feedback reaction to an increased intake of water is a(n) {increase~=decrease} in water reabsorption by the nephron.

//LEVEL:3 //RAND

The negative feedback reaction to an increased intake of water is a(n) {~=increase~decrease} in urine volume.

//LEVEL:3 //RAND The negative feedback reaction to an increased intake of water is a(n) {increase~=decrease} of urine osmolarity.

//LEVEL:3 //RAND The negative feedback reaction to an increased intake of water is a(n) {~=increase~decrease} of plasma osmolarity.

//LEVEL:3 //RAND When you drink water the plasma osmolarity {~=decreases~increases}. This has the effect of {increasing~=decreasing} the release ADH. This in turn {increases~=decreases} the production of aquaporins by the nephron causing {increased~=decreased} water reabsorption. Urine osmolarity will {increase~=decrease} while volume will {~=increase~decrease}. This will lead to plasma osmolarity {~=returning to normal~decreasing~=increasing}.

@@ 1行目: / 1行目: @@
-{{Point|飲水により、血漿浸透圧が低下すると、負のフィードバックにより、バゾプレッシン、抗利尿ホルモン anti-diuretic hormone (ADH)の生成・内分泌・血中濃度は低下する。}}
+{{Point|Intake of water will decrease plasma osmolarity.  This will in turn lead to a decrease in the synthesis, secretion and blood concentration of ADH.}}
 [[メディア:6-ADHcontrol-water.mp4|動画と音声での説明 ]]<br>
 <div class="avoid-page-break">
 [[ファイル:IncADHeffect1.jpg|left|500px]]
-[[メディア:ADHcontrol-water-start.mp4|飲水前の動画]]
+[[メディア:ADHcontrol-water-start.mp4|飲水前の動画]]<br>
-<br>
+Prior to drinking we assume our subject is in homeostasis with normal plasma and urine osmolarities and volumes.
-飲水の前は、恒常性が保たれていて、血漿浸透圧、尿浸透圧、尿量は正常であるとしましょう。
 <br style="clear:both;" />
 </div>
 <div class="avoid-page-break">
 [[ファイル:6-ADHcontrol-water1.jpg|left|500px]]
-飲水したとしましょう。水分が血漿に入り、血漿浸透圧は低下して低張になります。<br>
+Steps 1 and 2:  Water was taken.  Water will enter the plasma and its osmolarity will decrease.  Both intake of water and the ADH/water channels/reabsorption of water by the kidney will decrease plasma osmolarity, having the same effect.  Thus, in this case with low plasma osmolarity, the effect of ADH/water channels/reabsorption would be too much.
-<br>
+ [[メディア:ADHcontrol-water-middle.mp4|飲水直後、調節前の動画]]
-水の再吸収と飲水とは両方とも血漿浸透圧を下げます。このふたつは同じ方向であるため、バソプレッシン・ADH・水チャンネル・水分再吸収の血漿浸透圧低下作用が過剰になります。
-[[メディア:ADHcontrol-water-middle.mp4|飲水直後、調節前の動画]]
 <br style="clear:both;" />
 </div>
 <div class="avoid-page-break">
 [[ファイル:WaterDuringADHcontrol.jpg|left|500px]]
-このとき、負のフィードバックはバソプレッシン・ADHの生成・内分泌・血中濃度を低下します。バソプレッシン・ADHの水チャンネル増加作用が弱くなり、水チャンネルは減少します。これにより水分の再吸収は減少します。[[メディア:WaterDuringADHcontrol.mp4|飲水に対してADHが低下した直後の動画]]
+Steps 3 and 4:  With too much effect of ADH/water channels/reabsorption, the negative feedback decreases (the synthesis, secretion, and blood concentration of) ADH.  The ADH-facilitating effect on the water channels will decrease, decreasing the number of water channels.  This decreases the reabsorption of water by the kidney.
+ [[メディア:WaterDuringADHcontrol.mp4|飲水に対してADHが低下した直後の動画]]
 <br style="clear:both;" />
 </div>
 <div class="avoid-page-break">
 [[ファイル:6-ADHcontrol-water2.jpg|left|500px]]
-再吸収されて血漿に入るNa<sup>+</sup>の水分に対する比が増加し、血漿浸透圧は上昇します。これにより低下していた血漿浸透圧は正常へ向けて上がります。<br>
+Step 5:  The ratio of Na+ to water reabsorption by the kidney increases.  This means plasma osmolarity increases.  The decreased plasma osmolarity from intake of water will increase returning to normal.
-再吸収されて尿細管から出るNa<sup>+</sup>の水分に対する比が増加するため、尿浸透圧は低下します。水チャンネルも水分再吸収も減少するため、尿量は増えます。薄い尿が大量でてきます。
+Because a higher ratio of Na+ is reabsorbed the fluid left in the tubule now has a lower osmolarity.  The decrease in the number of water channels decreases water reabsorption so there is more water.  So overall the urine becomes dilute and high volume.
-[[メディア:ADHcontrol-water-end.mp4|飲水に対してADHが低下した後の血漿、尿の2次的変化の動画]]
+ [[メディア:ADHcontrol-water-end.mp4|飲水に対してADHが低下した後の血漿、尿の2次的変化の動画]]
 <br style="clear:both;" />
 </div>
 {{QuizTitle}}
 <GIFT>
 //LEVEL:2
 //RAND
-飲水に対する負のフィードバック調節として、バゾプレッシン、抗利尿ホルモン anti-diuretic hormone (ADH)の生成・内分泌・血中濃度は、{~亢進~=低下}する。
+The negative feedback reaction to an increased intake of water is a(n) {increase~=decrease} of ADH secretion.
 //LEVEL:3
 //RAND
-飲水に対する負のフィードバック調節として、尿細管の水チャンネルの数は　{~=少なくなる~多くなる}。
+ The negative feedback reaction to an increased intake of water is a(n) {increase~=decrease} of aquaporin channels in the kidney.
 //LEVEL:2
 //RAND
-飲水に対する負のフィードバック調節として、尿細管で再吸収される水分の量は　{多くなる~=少なくなる} 。
+The negative feedback reaction to an increased intake of water is a(n) {increase~=decrease} in water reabsorption by the nephron.
 //LEVEL:3
 //RAND
-飲水に対する負のフィードバック調節の結果、尿量は　{~=多くなる~少なくなる}。
+ The negative feedback reaction to an increased intake of water is a(n) {~=increase~decrease} in urine volume.
 //LEVEL:3
 //RAND
-飲水に対する負のフィードバック調節の結果、尿の浸透圧は　{上昇する~=低下する} 。
+The negative feedback reaction to an increased intake of water is a(n) {increase~=decrease} of urine osmolarity.
 //LEVEL:3
 //RAND
-飲水に対する負のフィードバック調節の結果、血漿浸透圧は(等張へ向けて){~=高くなる~低くなる}。
+The negative feedback reaction to an increased intake of water is a(n) {~=increase~decrease} of plasma osmolarity.
 //LEVEL:3
 //RAND
-飲水すると、血漿浸透圧は　{~上昇~=低下}する。これは、バゾプレッシン、抗利尿ホルモン anti-diuretic hormone (ADH)のホルモン作用(血漿浸透圧の　{~上昇~=低下})と{=同じ~逆の}方向であり、負のフィードバックによりバゾプレッシン、抗利尿ホルモン anti-diuretic hormone (ADH)の生成・内分泌・血中濃度は{~亢進~=低下}する。これにより、腎臓の尿細管の水チャンネル数は通常より{~多く~=少なく}なり、水分の再吸収は{~多く~=少なく}なる。これは尿量を{~減少~=増大}させ、尿浸透圧を{~増大~=減少}させ、血漿浸透圧を(等張へ向けて){=高く~低く}する。
+When you drink water the plasma osmolarity {~=decreases~increases}.  This has the effect of {increasing~=decreasing} the release ADH.  This in turn {increases~=decreases} the production of aquaporins by the nephron causing {increased~=decreased} water reabsorption. Urine osmolarity will {increase~=decrease} while volume will {~=increase~decrease}.  This will lead to plasma osmolarity {~=returning to normal~decreasing~=increasing}.
-</GIFT>

「SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/ControlToWaterIntake」の版間の差分

2019年5月21日 (火) 11:54時点における版

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