SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/EffectOfIncrease
| With an increase in the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), the number of water channels and water reabsorption increase. These decrease plasma osmolarity and urine volume, and also increase urine osmolarity. |
video prior to an increase in vasopressin (ADH)
Prior to vasopressin (ADH) increasing (at baseline), we will make the assumption that the subject is in homeostasis with normal plasma and urine osmolarities (isotonic) and urine volume.
video just after an increase in vasopressin (ADH)
Step 1: Suppose that the synthesis, secretion, and blood concentration of vasopressin (ADH) increases.
Step 2: The water channel-increasing effect of vasopressin (ADH) becomes stronger, which increases the number of water channels. This increases the reabsorption of water by the kidney.
video showing the changes in plasma and urine after the increase in vasopressin (ADH)
Step 3: With the increase in water reabsorption, diluted (hypotonic) solution enters the plasma. This decreases plasma osmolarity (becomes diluted, hypotonic). Because diluted (hypotonic) solution leaves the tubule due to reabsorption, the fluid remaining in the tubule has a higher osmolarity (concentrated, hypertonic). Also, with the increase in water reabsorption, there is less water remaining in the tubule. Overall, the urine becomes more concentrated (hypertonic) and decreases in volume.
Challenge Quiz
With an increase in the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), the number of water channels in the kidney increases decreases .
With an increase in the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), water reabsorption by the kidney increases decreases .
With an increase in the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), urine volume increases decreases .
With an increase in the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), urine osmolarity increases decreases .
With an increase in the synthesis, secretion, and blood concentration of vasopressin (anti-diuretic hormone, ADH), plasma osmolarity increases decreases .
The effect of increase in vasopressin (anti-diuretic hormone, ADH) is uterine smooth muscle contration a decrease in plasma osmolarity .
The effect of increase in vasopressin (anti-diuretic hormone, ADH) is an increase a decrease in plasma osmolarity.