Endocrinology/HormonesWithoutMuchPituitaryRole/GlucagonAndInsuliln/Glucagon/ControlBasic/Fasting
| When blood glucose is decreased, negative feedback facilitates glucagon (synthesis, secretion, and blood concentration). |
(Synthesis, secretion, and blood concentration of) glucagon increases blood glucose.
Glucagon has a certain (baseline) amount of synthesis, secretion, blood concentration, and blood glucose-increasing effect before fasting.
① Subject had fasted. Blood glucose is decreased due to the fasting. Glucacon (synthesis, secretion, and blood concentration) increases blood glucose. These are in the opposite direction (blue).
② Since these are in the opposite direction (blue)., negative feedback facilitate (red) glucagon (synthesis, secretion, and blood concentration). Because of this, the blood glucose-increasing effect of glucagon strengthens, and the decrease in blood glucose (blue downward unfilled arrow) disappears (decreased blood glucose increases to the baseline).
Like, when room temperature is decreased (winter), heater (function) is increased, this also is blue→red negative feedback.
室温が低下した時（冬）にヒーターは使う、と同様、青→赤の負のフィードバックです。
Challenge Quiz
絶食により血糖は 上昇 低下 し、グルカゴン（の生成、内分泌、血中濃度）は血糖を 上昇 低下 させる。これらは 同じ方向 逆の方向 であるので、負のフィードバックはグルカゴンを 低下 亢進 させる。この調節により、血糖の最初の変化は消える、すなわち血糖は(ベースラインへ向けて) 上昇 低下 する。
血糖が低下した時、負のフィードバックはグルカゴン（の生成、内分泌、血中濃度）を 亢進 低下 させる。