SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/ControlToSweating

POINT!

Sweating will increase plasma osmolarity. This will in turn lead to a increase in the synthesis, secretion and blood concentration of ADH.

Video and audio instructions

The video of prior to swating,発汗前の動画
Prior to sweating we assume our subject is in homeostasis with normal plasma and urine osmolarities and volumes.

The video of just after sweating,発汗直後、調節前
Steps 1 and 2: The subject sweated. Water will leave the plasma and its osmolarity will increase. Sweating will increase and the ADH/water channels/reabsorption of water by the kidney will decrease plasma osmolarity, having the opposite effect. Thus, in this case with high plasma osmolarity, the effect of ADH/water channels/reabsorption would be too little.

The video of just after 発汗に対してADHが亢進した直後の動画
Steps 3 and 4: With too little effect of ADH/water channels/reabsorption, the negative feedback increases (the synthesis, secretion, and blood concentration of) ADH. The ADH-facilitating effect on the water channels will increase, increasing the number of water channels. This increases the reabsorption of water by the kidney.

発汗に対してADHが亢進した後の血漿、尿の2次的変化の動画
Step 5: The ratio of Na+ to water reabsorption by the kidney decreases. This means plasma osmolarity decreases. The decreased plasma osmolarity from sweating will decrease returning to normal. Because a lower ratio of Na+ is reabsorbed the fluid left in the tubule now has a higher osmolarity. The increase in the number of water channels increases water reabsorption so there is less water. So overall the urine becomes high concentration and low volume.

Challenge Quiz

<GIFT> //LEVEL:2 //RAND The negative feedback reaction to an increased sweating is a(n) {~=increase~decrease} of ADH secretion.

//LEVEL:3 //RAND The negative feedback reaction to an increased sweating is a(n) {~=increase~decrease} of aquaporin channels in the kidney.

//LEVEL:2 //RAND The negative feedback reaction to an increased sweating is a(n) {~=increase~decrease} in water reabsorption by the nephron.

//LEVEL:3 //RAND The negative feedback reaction to an increased sweating is a(n) {increase~=decrease} in urine volume.

//LEVEL:3 //RAND The negative feedback reaction to an increased sweating is a(n) {~=increase~decrease} of urine osmolarity.

//LEVEL:3 //RAND The negative feedback reaction to an increased sweating is a(n) {increase~=decrease} of plasma osmolarity.

//LEVEL:3 //RAND When you sweat the plasma osmolarity {decreases~=increases}. This has the effect of {~=increasing~decreasing} the release ADH. This in turn {~=increases~decreases} the production of aquaporins by the nephron causing {~=increased~decreased} water reabsorption. Urine osmolarity will {~=increase~decrease} while volume will {increase~=decrease}. This will {~=decreasing~increasing} plasma osmolarity {~=returning to normal~separating from normal}.