SHolroydAtWeilCornellMedQatar/Endocrinology/VasopressinADH/ControlToSweatingのソースを表示

{{Point|Sweating will increase plasma osmolarity.  This will in turn lead to a increase in the synthesis, secretion and blood concentration of ADH.}}

[[メディア:6-ADHcontrol-sweat.mp4|narrated video explanation]]

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[[ファイル:ADHbaseline.jpg|left|500px]]
[[メディア:ADHcontrol-water-start.mp4|video prior to sweating]]<br>
Prior to sweating, we assume our subject is in homeostasis with normal plasma and urine osmolarities and volumes.
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[[ファイル:ADHControlToSweating1Eng.jpg|left|500px]]
[[メディア:ADHcontrol-sweat-middle.mp4|video just after sweating]]<br>
Steps 1 and 2:  The subject sweated. Water will leave the plasma and its osmolarity will increase.  Sweating will increase, and the ADH/water channels/reabsorption of water by the kidney will decrease plasma osmolarity, having the opposite effect.  Thus, in this case with high plasma osmolarity, the effect of ADH/water channels/reabsorption would be too little.
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[[ファイル:ADHControlToSweating2Eng.jpg|left|500px]]
[[メディア:WaterDuringADHcontrol.mp4|video just after ADH increased responding to sweating]]<br>
Steps 3 and 4:  With too little effect of ADH/water channels/reabsorption, the negative feedback increases (the synthesis, secretion, and blood concentration of) ADH.  The ADH-facilitating effect on the water channels will increase, increasing the number of water channels.  This increases the reabsorption of water by the kidney.
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[[ファイル:ADHControlToSweating3Eng.jpg|left|500px]]
[[メディア:ADHcontrol-sweat-end.mp4|video showing the changes in plasma and urine after ADH increased responding to sweating]]<br>
Step 5:  The ratio of Na<sup>+</sup> to water reabsorption by the kidney decreases.  This means plasma osmolarity decreases.  The increased plasma osmolarity from sweating will decrease returning to normal.   
Because a lower ratio of Na<sup>+</sup> is reabsorbed the fluid left in the tubule now has a higher osmolarity.  The increase in the number of water channels increases water reabsorption so there is less water.  So overall the urine becomes more concentrated and low volume.
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{{QuizTitle}}
<GIFT>
//LEVEL:2 
//RAND 
The negative feedback response to an increased sweating is a(n) {~=increase~decrease} of ADH secretion.

//LEVEL:3 
//RAND 
The negative feedback response to an increased sweating is a(n) {~=increase~decrease} of water channels in the kidney. 

//LEVEL:2 
//RAND 
The negative feedback response to an increased sweating is a(n) {~=increase~decrease} in water reabsorption by the nephron.

//LEVEL:3 
//RAND 
The negative feedback response to an increased sweating is a(n) {increase~=decrease} in urine volume. 

//LEVEL:3 
//RAND 
The negative feedback response to an increased sweating is a(n) {~=increase~decrease} of urine osmolarity.

//LEVEL:3 
//RAND 
The negative feedback response to an increased sweating is a(n) {increase~=decrease} of plasma osmolarity.

//LEVEL:3 
//RAND 
When you sweat the plasma osmolarity {decreases~=increases}.  This has the effect of {~=increasing~decreasing} (the synthesis, secretion, and blood concentration of) ADH.  This in turn {~=increases~decreases} the number of water channels by the nephron causing {~=increased~decreased} water reabsorption. Urine osmolarity will {~=increase~decrease} while volume will {increase~=decrease}.  This will {~=decrease~increase} plasma osmolarity, {~=returning to normal~separating from normal}.
</GIFT>